Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

However, the opioid pathway, a heavily studied physiologic pathway inextricably intertwined with behaviour and reward, rarely receives attention within psychiatric practice. Although the opioid system ...

Researchers at Scripps Research have redesigned fentanyl at the molecular level, challenging decades-old assumptions about opioid chemistry.

Opioids slot into opioid receptors and activate them. This sends signals to your brain to relieve pain and promote pleasure. Both endogenous opioids, which your body naturally produces, and exogenous ...

Visual Abstract. Whole-body [11C] carfentanil PET imaging at baseline (left side of panel) and then following naloxone (middle panel) shows μ-opioid receptor (MOR) in the brain (color) and throughout ...

Opioid agonists are substances that activate opioid receptors in the central and peripheral nervous systems. They have several uses, from pain management to treating opioid use disorder. You have ...

Brain volume and function are altered in individuals with opioid use disorder, a new Yale study finds. Using magnetic resonance imaging (MRI) and functional MRI (fMRI), researchers observed the ...

Fentanyl is one of the most effective drugs for managing severe pain, yet it carries substantial risks of addiction and ...

A novel compound strongly improves the efficacy of naloxone, the substance used to reverse overdoses of morphine, fentanyl and other opioid drugs. When administered to mice along with naloxone, it is ...

Naloxone (also known as Narcan, the commonly used drug to treat narcotic overdoses) has greater binding to opioid receptors in women's brains than in men's brains, according to new research published ...