A team of researchers led by Professor Akitsu Hotta (Department of Clinical Application) developed a comprehensive framework ...

Research led by the University of Cambridge Loke Centre for Trophoblast Research has shown that a genome editing technique ...

A new study uses precise base editing on human embryos for the first time, proving the NANOG gene is the master switch for body development.

CRISPR Cas9 genome editing has transformed the way scientists approach gene therapy, acting like precise DNA scissors that can target and repair hereditary diseases at the genetic level. This ...

We performed both homology-based and GUIDE-seq nomination of candidate off-target sites, which resulted in the testing of 5002 sites from four healthy donors (not shown). We then nominated additional ...

The CRISPR–Cas system has become a worldwide genome editing tool for various organisms. Its precision and efficiency have facilitated basic research, drug discovery and therapeutic interventions. In ...

Rapid advances in sequencing technologies have greatly improved our ability to generate massive amounts of genomic data. This avalanche of data is only the first step in the true goal of biologists, ...

Since the landmark discovery that a bacterial defense mechanism could be repurposed into programmable “molecular scissors,” CRISPR-Cas9 gene-editing technology has undergone a major evolution. Over ...