Statins are a cornerstone of heart health, but muscle pain and weakness cause many patients to quit taking them. Scientists have now identified the precise molecular trigger behind these side effects.
Managing Calcium Overload Identified as Novel Therapeutic Approach in Treating Injured Muscle Fibers
Mutations in a calcium ion channel anoctamin 5 (ANO5), commonly found in muscle cells, cause the debilitating disease called limb girdle muscular dystrophy 2L (LGMD2L). Characterized by progressive ...
According to Marks, this calcium leak may explain muscle pain and weakness linked to statins. The excess calcium can weaken muscle fibers directly or activate enzymes that gradually break down muscle ...
Cells have to invest a lot of energy to maintain this concentration gradient, especially when it comes to getting rid of calcium. 'It's like being on a rush-hour train in a city like Tokyo. When the ...
Figure 1: Structures of calcium pump before (left) and after (right) it has transported ions into the sarcoplasmic reticulum (A, N, P: three cytoplasmic domains; TM ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results