The authors offer recommendations for permissible daily exposures and concentration limits of elemental impurities for dermal drug products. The International Council for Harmonization Guideline for ...
The 11 known phosphodiesterase (PDE) families comprise at least 60 distinct PDE species. They differ in their substrate specificity, their kinetic properties, and in their tissue distribution (Table 1 ...
In this study, the authors investigated the relationship between the 0.001 MinDD and the PDE values for 140 drug substances as an attempt to identify high-risk groups of products for patient safety.
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