At the turn of the century, the biomedical research community saw a landmark global effort, when scientists built a reference human genome sequence to better understand the genes underlying health and ...

Researchers from Children's Hospital of Philadelphia (CHOP) developed a new RNA sequencing strategy that can reveal how genetic variants disrupt gene function and improve the diagnosis of rare ...

Accurate RNA splicing is essential for gene expression and human health, yet predicting how DNA sequence variations affect ...

Human gene maps contain major blind spots because they were built largely from the DNA sequences of people with European ancestry, according to a study published in Nature Communications. Researchers ...

While RNA sequencing (RNA-seq) has become a standard tool for profiling which genes are active in an organism, determining the actual biological functions of those genes in fungi remains a significant ...

EMBL researchers created SDR-seq, a next-generation tool that decodes both DNA and RNA from the same cell. It finally opens access to non-coding regions, where most disease-associated genetic variants ...

A research team has mapped how 5-methylcytosine (m5C), an RNA methylation mark, changes in tomato fruits after infection by ...

The authors of the study pictured in the facilities housing MareNostrum5, the supercomputer which was critical for processing the vast amounts of data generated by the study. Human gene maps contain ...