Background. Novel therapeutic targets are needed to improve the outcome of individuals with cancer. EG-011 is a small molecule with in vitro and in vivo anti-tumor activity in lymphoma and acute ...
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Abstract. High-throughput screening (HTS) of cereblon (CRBN) molecular glue (MG)-biased libraries remains a key strategy for proof-of-concept studies and hit identification against emerging targets.
Colorectal cancer (CRC) remains a significant public health challenge, with an urgent need of novel prognostic biomarkers and therapeutic targets. PTK7, a membrane tyrosine pseudokinase and Wnt ...
TenSixty Biosciences employs an innovative AI-enhanced multi-omics discovery framework to enable the development of next-generation antibody-drug conjugates (ADCs). This integrated approach identified ...
Background: IL-12 is a key mediator of antitumor immune response. In preclinical models, IT IL-12 mRNA led to IFNγ release and CD8+ T cell-dependent tumor regression and potentiated PD-L1 blockade.
Abstract. The cancer preventive activity of vitamin E has been suggested by many epidemiologic studies. However, several recent large-scale human trials with α-tocopherol, the most commonly recognized ...
1Pancreas Center, National Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, ...
Cancer Discov (2026) 16 (7): OF1.
Cancer Discov (2026) 16 (7): OF1.
NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio ® (avelumab), a ...
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