A storm system sweeping over large areas of the U.S. South and Midwest resulted in at least 16 weather-related deaths by early Sunday, with overnight tornado and flash flood warnings setting up more severe weather that forecasters say could cause rising waterways for days to come.

Another round of torrential rain and flash flooding has come for parts of the South and Midwest already heavily waterlogged by days of deadly storms.

At least 16 people have been killed in a wide swath of violent storms, flooding and tornadoes that hit the South and Midwest.

A storm system sweeping over large areas of the U.S. South and Midwest has resulted in at least 16 weather-related deaths, with overnight tornado and flash flood warnings setting up more severe weather.

As communities in the central US grapple with widespread devastation from a line of deadly storms that spawned dozens of tornadoes this week, forecasters are warning of another grave threat to the region: relentless rain into the weekend,

About 22 million people are at risk for severe storms Sunday, stretching from central North Carolina southwestward to the central Gulf Coast, according to the Storm Prediction Center.

After a devastating tornado ripped through the town on Wednesday, Dyersburg (Tenn.) residents had to take shelter three more times on Saturday due to tornado warnings as they prepared for possible flooding from heavy rains earlier.

Waters continued to rise in communities from Arkansas to Michigan as the storm, which has killed at least eight, drenched the region. More tornadoes were also possible.